Journal
NANO LETTERS
Volume 10, Issue 9, Pages 3684-3691Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl102180s
Keywords
Colloidal mesoporous silica; nanoparticles; endosomal release; photosensitizer; redox-sensitive disulfide linker; drug delivery
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Funding
- Nanosystems Initiative Munich (NIM), DFG [SFB 749]
- Center for Integrated Protein Science Munich (CIPSM)
- Center for Nano-Science (CeNS)
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Redox-driven intracellular disulfide-cleavage is a promising strategy to achieve stimuli-responsive and controlled drug release. We synthesized colloidal mesoporous silica (CMS) nanoparticles with ATTO633-labeled cysteine linked to the inner particle core via disulfide-bridges and characterized their cysteine release behavior after internalization into HuH7 cells by high-resolution fluorescence microscopy. Our study revealed that endosomal escape is a bottleneck for disulfide-linkage based drug release. Photochemical opening of the endosome leads to successful delivery of fluorescently labeled cysteine to the cytosol.
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