Journal
NANO LETTERS
Volume 10, Issue 1, Pages 52-58Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl902659g
Keywords
Angiogenesis; magnetic resonance imaging; molecular imaging; synergistic targeting; anti-angiogenic therapy
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Funding
- BSIK project entitled Molecular Imaging of Ischemic Heart Disease [BSIK03033]
- European Network of Diagnostic Molecular Imaging (DIMI) [LSHB-CT-2005-512146]
- Integrated European Union Project Targeted Delivery of Nanomedicine [FP6_2004_NMP_NI_4/IP 026668_2]
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Effective and specific targeting or nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the Current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.
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