4.8 Article

Light-Induced Local Heating for Thermophoretic Manipulation of DNA in Polymer Micro- and Nanochannels

Journal

NANO LETTERS
Volume 10, Issue 3, Pages 826-832

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/nl903190q

Keywords

Lab-on-a-chip; opto-thermal actuation; thermophoresis

Funding

  1. Danish Research Council for Technology and Production [274-050375]
  2. EC [HEALTH-F4-2008-201418]

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We present a method for making polymer chips with a narrow-band near-infrared absorber layer that enables light-induced local heating of liquids inside fluidic micro- and nanochannels fabricated by thermal imprint in polymethyl methacrylate. We have characterized the resulting liquid temperature profiles in microchannels using the temperature dependent Fluorescence of the complex [Ru(bpy)(3)](2+). We demonstrate thermophoretic manipulation of individual YOYO-1 stained T4 DNA molecules inside micro- and nanochannels.

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