Journal
NANO LETTERS
Volume 10, Issue 1, Pages 219-223Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl903313r
Keywords
Apoferririn; ferritin receptor; nanoparticle; platinum; ROS
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Funding
- German Ministry of Education and Research (BMBF) [03X5507]
- State of Saxony-Anhalt Life Sciences Excellence Initiative [X133599HP/0105T]
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The great potential for medical applications of inorganic nanoparticles in living organisms is severely restricted by the concern that nanoparticles can harmfully interact with biological systems, such as lipid membranes or cell proteins. To enable an uptake of such nanoparticles by cells without harming their membranes, platinum nanoparticles were synthesized within cavities of hollow protein nanospheres (apoferritin). In vitro, the protein-platinum nanoparticles show good catalytic efficiency and long-term stability. Subsequently the particles were tested after ferritin-receptor-mediated incorporation in human intestinal Caco-2 cells. Upon externally induced stress, for example, with hydrogen peroxide, the oxygen species in the cells decreased and the viability of the cells increased.
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