Journal
NANO LETTERS
Volume 10, Issue 5, Pages 1823-1830Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl100533c
Keywords
Traction force; mechanotransduction; cell motility; rigidity sensing
Categories
Funding
- ETH Zurich
- Deutsche Forschungsgemeinschaft
- Nanotechnology Center for Mechanics in Regenerative Medicine
- National Institutes of Health Roadmap Nanomedicine Development Center
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Quantifying cellular forces relies on accurate calibrations of the sensor stiffness. Neglecting deformations of elastic substrates to which elastic pillars are anchored systematically overestimates the applied forces (up to 40%). A correction factor considering substrate warping is derived analytically and verified experimentally. The factor scales with the dimensionless pillar aspect ratio. This has significant implications when designing pillar arrays or comparing absolute forces measured on different pillar geometries during cell spreading, motility, or rigidity sensing.
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