Journal
NANO LETTERS
Volume 10, Issue 7, Pages 2484-2492Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl100991w
Keywords
Supported lipid bilayer; colloidal mesoporous silica nanoparticles; monodisperse colloidal suspension; drug release-on-demand; colchicine; living cancer cells
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Funding
- DFG [SFB 486, SFB 749]
- NIM and CIPSM Excellence Cluster (LMU Munchen)
- CeNS
- Elitenetzwerk Bayern
- Romer foundation
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We report on a one-step assembly route where supported lipid bilayers (SLB) are deposited on functionalized colloidal mesoporous silica (CMS) nanoparticles, resulting in a core shell hybrid system (SLB@CMS) The supported membrane acts as an intact barrier against the escape of encapsulated dye molecules These stable SLB@CMS particles loaded with the anticancer drug colchicine are readily taken up by cells and lead to the depolymerization of microtubules with remarkably enhanced efficiency as compared to the same dose of drug in solution
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