Journal
NANO LETTERS
Volume 10, Issue 3, Pages 782-787Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl902675h
Keywords
Mechanosensing; cellular force; picoNewton; nanowire; neuron
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We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the Fine details of growth-cone dynamics.
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