Journal
NANO LETTERS
Volume 10, Issue 4, Pages 1189-1193Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl1000086
Keywords
DNA; multiplex; pathogen; pattern; surface-enhanced Raman scattering
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Funding
- NRE through NRL [20090083138]
- Nano RD program [20090083221]
- SRC [2010-0001484]
- MEST [2009K000468]
- Ministry of Knowledge Economy through IITA
- Ministry of Education, Science & Technology (MoST), Republic of Korea [KIB 1] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [R32-2008-000-10142-0, 15-2008-07-001-00, 2008-2002824, 2008-0057805, 2007-0056784] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A Au particle-on-wire system that can be used as a specific, sensitive, and multiplex DNA sensor is developed. A pattern formed by multiple Au nanowire sensors provides positional address and identification for each sensor. By using this system, multiplex sensing of target DNAs was possible in a quantitative manner with a detection limit of 10 pM. Target DNAs from reference bacteria and clinical isolates were successfully identified by this sensor system, enabling diagnostics for infectious diseases.
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