Journal
NANO LETTERS
Volume 10, Issue 10, Pages 3914-3921Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl102485v
Keywords
Magnetic retention; gene therapy; RNA interference; magnetic NPs; delivery; lipospheres
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Funding
- BMBH ERA-NET NEURON
- German Federal Ministry of Education and Research [3N8186, 13N8538]
- German Excellence Initiative via the Nanosystems Initiative Munich (NIM)
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Lipospheres made from soy bean oil and a combination of the cationic lipid Metafectenc and the helper lipid dioleoylphosphaudyl-ethanolamine were functionalized with magnetic nanoparticles (NPs) and small interfering RNA (sIRNA) The resulting magnetic lipospheres loaded with siRNA are proven here as efficient nonviral vectors for gene silencing Embedding magnetic NPs in the shell of lipospheres allows for magnetic force-assisted transfection (magnetofection) as well as magnetic targeting in both static and fluidic conditions mimicking the bloodstream
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