Journal
NANO LETTERS
Volume 10, Issue 11, Pages 4549-4554Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl103142t
Keywords
Gold nanoparticles; laser irradiation; photothermal effects; HeLa cells
Categories
Funding
- European Union (NACARDIO)
- BBSRC [BB/C520471/1]
- STFC Central Laser Facility
- Biotechnology and Biological Sciences Research Council [BB/C520471/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/G03088X/1] Funding Source: researchfish
- EPSRC [EP/G03088X/1] Funding Source: UKRI
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We show that low-intensity laser irradiation of cancer cells containing endosomal gold nanoparticles leads to endosome rupture and escape of the nanoparticles into the cytosol without affecting the cells' viability. The low light intensity of our experiments allows us to rule out photothermal effects as the underlying mechanism, and we present results that suggest photoinduced radicals as the photogenerated active species. This nonthermal mechanism may also he important in the context of cell death at higher laser intensities, which had been reported previously.
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