Journal
NANO LETTERS
Volume 10, Issue 11, Pages 4607-4613Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl102623x
Keywords
SPIO; MRI contrast agent; nuclear relaxation; molecular imaging
Categories
Funding
- National Institutes of Health [HHSN268201000043C]
- Center of Cancer Nanotechnology [CA119338]
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We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by One-tuning the core size and PEG coating of SPIOs, the T-2 relaxivity per particle can be increased by >200-Fold. With 14 nm core and PEG1000 coating, SPIOs can have T-2 relaxivity of 385 s(-1) mM(-1), which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.
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