Journal
NANO LETTERS
Volume 10, Issue 6, Pages 2211-2219Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl101157z
Keywords
Mesoporous silica; nanoparticles; P-glycoprotein; drug delivery; photodynamic therapy; endosome
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Funding
- MIT Deshpande Center for Technological Innovation
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Nanoparticle (NP)-mediated drug delivery typically relies on cargo release to occur passively or in response to environmental stimuli. Here we present a delivery method based on light-activated disruption of intracellular vesicles after internalization of biofunctionalized mesoporous silica nanoparticles loaded with cargo. This method combines the power of targeted delivery with the spatiotemporal control of light activation. As an example, we delivered a cell-impermeable fluorescent compound exclusively to the cytosol of multidrug resistant cancer cells in a mixed population.
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