Journal
NANO LETTERS
Volume 10, Issue 9, Pages 3656-3664Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl102100m
Keywords
Quantum dots; nanoparticles; surface modifications; inflammation; in vivo microscopy; microcirculation
Categories
Funding
- Bio-Imaging Network of Ludwig-Maximilians-Universitat Munchen
- Friedrich-Baur-Stiftung
- European Union
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Although different nanosized materials, including quantum dots (QDs), are intended to be used for biomedical applications, their interactions with microvessels and their inflammatory potential are largely unknown. In this in vivo study we report that leukocyte recruitment is modulated in the presence of quantum dots. We found that the surface chemistry of QDs strongly affects their localization in postcapillary venules, their uptake by perivascular macrophages, and their potential to modify steps of leukocyte recruitment.
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