Journal
NANO LETTERS
Volume 9, Issue 3, Pages 1111-1116Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl803548b
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Funding
- Chinese Ministry of Science and Technology [2009CB930000, 2005CB522700]
- National Science Foundation of China [50533010, 20774020]
- Chinese Ministry of Education [305004]
- Science and Technology Developing Foundation of Shanghai [07JC14005]
- Shanghai Education Committee [B 112]
- Landesstiftung Baden-Wiirttemberg
- Max Planck Society
- National Institutes of Health [PN2 EY 016586]
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We herein present a novel platform of well-controlled ordered and disordered nanopatterns positioned with a cyclic peptide of arginine-glycine-aspartic acid (RGD) on a bioinert poly(ethylene glycol) background, to study whether the nanoscopic order of spatial patterning of the integrin-specific ligands influences osteoblast adhesion. This is the first time that the nanoscale order of RGD ligand patterns was varied quantitatively, and tested for its impact on the adhesion of tissue cells. Our findings reveal that Integrin clustering and such adhesion induced by RGD ligands Is dependent on the local order of ligand arrangement on a substrate when the global average ligand spacing is larger than 70 nm; i.e., cell adhesion Is turned off by RGD nanopattern order and turned on by the RGD nanopattern disorder if operating at this range of interligand spacing.
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