Journal
NANO LETTERS
Volume 9, Issue 6, Pages 2280-2284Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl900437n
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Funding
- National Basic Research Program of China [2009CB930103]
- American Lebanese Syrian Associated Charities
- St. Jude Children's Research Hospital
- NATIONAL CANCER INSTITUTE [P30CA021765] Funding Source: NIH RePORTER
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Although carbon nanotubes (CNTs) have been shown to nonspecifically bind proteins through charge complementary, pi-pi stacking or hydrophobic interactions, they have not been shown to bind to a specific site on proteins. By generating surface molecular diversity, we created functionalized CNTs that recognize and bind to the catalytic site of a-chymotrypsin and inhibit its enzymatic activity competitively.
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