Journal
NANO LETTERS
Volume 9, Issue 1, Pages 308-311Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl802958f
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Funding
- Cancer Center for Nanotechnology Excellence (CCNE)
- LUNGevity Foundation
- American Cancer Society Postdoctoral Fellowship in Lung Cancer
- Ryan Fellowship
- NATIONAL CANCER INSTITUTE [U54CA119341] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD000285] Funding Source: NIH RePORTER
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Polyvalent oligonucleotide gold nanoparticle conjugates have unique fundamental properties including distance-dependent plasmon coupling, enhanced binding affinity, and the ability to enter cells and resist enzymatic degradation. Stability in the presence of enzymes is a key consideration for therapeutic uses; however the manner and mechanism by which such nanoparticles are able to resist enzymatic degradation is unknown. Here, we quantify the enhanced stability of polyvalent gold oligonucleotide nanoparticle conjugates with respect to enzyme-catalyzed hydrolysis of DNA and present evidence that the negatively charged surfaces of the nanoparticles and resultant high local salt concentrations are responsible for enhanced stability.
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