Journal
NANO LETTERS
Volume 9, Issue 8, Pages 2825-2831Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl802929u
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Funding
- National Institutes of Health [EB008101, CA103830]
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Gold nanoparticles targeting epidermal growth factor receptor via antibody conjugation undergo molecular specific aggregation when they bind to receptors on cell surfaces, leading to a red shift in their plasmon resonance frequency. Capitalizing on this effect, we demonstrate the efficacy of the molecular specific photoacoustic imaging technique using subcutaneous tumor-mimicking gelatin implants in ex-vivo mouse tissue. The results of our study suggest that highly selective and sensitive detection of cancer cells is possible using multiwavelength photoacoustic imaging and molecular specific gold nanoparticles.
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