Journal
NANO LETTERS
Volume 9, Issue 5, Pages 1932-1936Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl9001052
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Funding
- Sandler Family Foundation and the National Science Foundation (NSEC)
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In this study, TiO2 nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanotubes was bioactive and decreased cell proliferation in vitro. Elution kinetics was most profoundly affected by tube height. This study demonstrates that TiO2 nanotubes may be a promising candidate for a drug-eluting implant coating.
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