Journal
NANO LETTERS
Volume 9, Issue 2, Pages 716-720Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl803219f
Keywords
-
Categories
Funding
- Nanosys, Inc.
- University of California
- National Institutes of Health [R01 EB002687]
- Sandier Family Foundation
- Rogers Foundation
- National Science Foundation [0425941]
- U.S. Department of Energy [DE-AC02-05CH 11231]
- NSF GRFP
Ask authors/readers for more resources
Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.(1-3) While some chemically modified, microstructured surfaces have been studied in aqueous environments 4,5 adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents under shear, and can increase the lift-off force 100-fold. We have shown that nanowire coatings, paired with epithelial physiology, significantly increase adhesion in mucosal conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available