Journal
NANO LETTERS
Volume 9, Issue 12, Pages 4533-4538Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl902935b
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Funding
- David and Lucile Packard Foundation [BRBAA07-E-2-0042]
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Target proteins can be functionally encapsulated using a cocoon-like polymeric nanocapsule formed by interfacial polymerization. The nanocapsule is cross-linked by peptides that can be proteolyzed by proteases upon which the protein cargo is released. The protease-mediated degradation process can be controlled in a spatiotemporal fashion through modification of the peptide cross-linker with photolabile moieties. We demonstrate the utility of this approach through the cytoplasmic delivery of the apoptosis inducing caspase-3 to cancer cells.
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