Journal
NANO LETTERS
Volume 9, Issue 9, Pages 3308-3311Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl901589y
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Funding
- Academy of Finland [128477, 131034]
- European Union
- Pentti Borg foundation
- Academy of Finland (AKA) [128477, 131034, 131034, 128477] Funding Source: Academy of Finland (AKA)
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Targeted nanoparticle-mediated intracellular delivery is demonstrated using two hydrophobic fluorophores as model drug cargo. The presented hybrid carrier system exhibits both cancer cell-targeting ability and capacity to retain a hydrophobic agent with subsequent specific release into the endosomal compartment. Furthermore, the incorporated agent is shown to be able to escape from the endosomes into the cytoplasm, making the particles promising candidates as carriers for targeted drug delivery for cancer treatment.
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