Journal
NANO LETTERS
Volume 8, Issue 10, Pages 3538-3542Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl8017912
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Funding
- Department of Defense/Defense Microelectronics Activity [DOD/DMEA-H94003-06-2-0608]
- National Institute of Mental Health [R01 MH 069791]
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We report the use of chemically functionalized water soluble single-walled carbon nanotube (SWNT) graft copolymers to inhibit endocytosis. The graft copolymers were prepared by the functionalization of SWNTs with polyethylene glycol. When added to the culturing medium, these functionalized water soluble SWNTs were able to increase the length of various neuronal processes, neurites, as previously reported. Here we have determined that SWNTs are able to block stimulated membrane endocytosis in neurons, which could then explain the previously noted extended neurite length.
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