Journal
NANO LETTERS
Volume 8, Issue 5, Pages 1492-1500Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl080496z
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Funding
- NCI NIH HHS [P30 CA016672, P30 CA-16675, CA16672] Funding Source: Medline
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We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.
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