Journal
NANO LETTERS
Volume 8, Issue 8, Pages 2517-2525Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl801596a
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Funding
- NIH-NCI [5R24 CA095823-04]
- NSF Major Research Instrumentation [DBI-9724504]
- NIH [1 S10 RR0 9145-01]
- NIH/NHLBI [R01 HL71021, R01 HL78667]
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Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics.
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