Journal
NANO LETTERS
Volume 8, Issue 9, Pages 2800-2805Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl801362a
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Funding
- NIH [T32 CA09695-15]
- [NCI CCNE U54 CA119367]
- [NIBIB BRP 5-RO1-EBB000312]
- [ICMIC P50 CA114747]
- NATIONAL CANCER INSTITUTE [P50CA114747, U54CA119367, R01CA119053, R21CA102123, T32CA009695] Funding Source: NIH RePORTER
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An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor (p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.
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