Adenosine triphosphate-selective fluorescent turn-on response of a novel thiazole orange derivative via their cooperative co-assembly

A novel thiazole orange (TO) derivative 3 has been synthesized and it could give the fluorescence turn-on responsive signal upon binding to nucleotides and besides, it exhibits high selectivity toward adenosine triphosphate (ATP) over other tested nucleotides. The nonlinear sigmoidal-responded pattern of the fluorescent spectra of 3 upon binding to ATP indicates that the positive cooperative interactions amplify the selective information. A possible co-assembled process of 3/ATP is postulated based on the UV-vis, fluorescent, H-1 NMR and DLS titrations. (C) 2014 Elsevier B.V. All rights reserved.