Journal
NANO LETTERS
Volume 8, Issue 5, Pages 1517-1526Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl080250u
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- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1004218] Funding Source: National Science Foundation
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We studied the effect of two types of mesoporous silica nanoparticles, MCM-41 and SBA-15, on mitochondrial O-2 consumption (respiration) in HL-60 (myeloid) cells, Jurkat (lymphoid) cells, and isolated mitochondria. SBA-15 inhibited cellular respiration at 25-500 mu g/mL; the inhibition was concentration-dependent and time-dependent. The cellular ATP profile paralleled that of respiration. MCM-41 had no noticeable effect on respiration rate. In cells depleted of metabolic fuels, 50 mu g/mL SBA-15 delayed the onset of glucose-supported respiration by 12 min and 200 mu g/mL SBA-15 by 34 min; MCM-41 also delayed the onset of glucose-supported respiration. Neither SBA-15 nor MCM-41 affected cellular glutathione. Both nanoparticles inhibited respiration of isolated mitochondria and submitochondrial particles.
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