Journal
NANO LETTERS
Volume 8, Issue 4, Pages 1131-1136Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl073290r
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Funding
- NCI NIH HHS [U54 CA119342-040001, U54 CA119342, U54 CA136398, U54 CA136398-010003] Funding Source: Medline
- NHLBI NIH HHS [R01 HL073646, R01 HL078631-02, R01 HL078631, R01 HL078631-01, R01 HL078631-04, R01 HL078631-03, R01 HL 073646] Funding Source: Medline
- NINDS NIH HHS [R01 NS059302-01, R01 NS059302, R01 NS059302-02] Funding Source: Medline
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The therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic degradation. We report the first stable incorporation of melittin (a 26 amino acid amphipathic peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly to the nanoparticles (dissociation constant similar to 3.27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.
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