Journal
NANO LETTERS
Volume 8, Issue 11, Pages 3715-3723Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl801958b
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Funding
- NIH/NHLB1 [ROI HL71021, R01 HL78667]
- NIH-National Cancer Institute [5R24 CA095823-04]
- National Science Foundation [DBI9724504]
- NIH [1 S 10 RR0 9145-01]
- NIH Small-Animal imaging Research Program (SAIRP) [R24 CA83084]
- NIH Center [P30 CA08748]
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High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL.
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