Journal
NANO LETTERS
Volume 8, Issue 9, Pages 2829-2833Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl801429p
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Funding
- U.S. National Institutes of Health [AI065359]
- U.S. National Science Foundation
- Center on Functional Engineered Nano Architectonics (FENA)
- Center for Scalable and Integrated NanoManufacturing
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Proteins assembled on an Au nanowire are manipulated by an electrical potential applied on the nanowire, which leads to the modulation of molecular fluorescence. The molecular modality can be unequivocally correlated with the modulated fluorescence, which enables the specific fluorescence from a single target protein to be unambiguously distinguished from background noise and nonspecific fluorescence. As demonstrated through a thrombin assay, this simple method can significantly improve the sensitivity and specificity of the protein detection down to the single molecule level.
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