Journal
NANO LETTERS
Volume 8, Issue 10, Pages 3503-3509Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl080537r
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Funding
- National Science Foundation
- Nano-Science Interdisciplinary Research Team (NIRT) [LHR, HGM, SHT, MCB-0210690]
- NSF IGERT [BCN, DGE-0114443]
- NIH Biotechnology Training Award [MY, T32 GM067555]
- California NanoSystems Institute
- [DMR-0114002]
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We demonstrate that a semiconducting polymer [poly(2-methoxy-5-propyloxy sulfonate phenylene vinylene), MPS-PPV] can be encapsulated inside recombinant, self-assembling protein nanocapsules called vaults. Polymer incorporation into these nanosized protein cages, found naturally at similar to 10,000 copies per human cell, was confirmed by fluorescence spectroscopy and small-angle X-ray scattering. Although vault cellular functions and gating mechanisms remain unknown, their large internal volume and natural prevalence within the human body suggests they could be used as carriers for therapeutics and medical imaging reagents. This study provides the groundwork for the use of vaults in encapsulation and delivery applications.
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