Journal
NANO LETTERS
Volume 8, Issue 6, Pages 1729-1735Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl0808132
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Funding
- NINDS NIH HHS [R21 NS 050346-01, R21 NS050346-02, R21 NS050346] Funding Source: Medline
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Trace detection of the conformational transition of beta-amyloid peptide (A beta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe A beta in different conformational states during the A beta self-assembly process as well as to distinguish A beta from confounder proteins commonly found in cerebral spinal fluid.
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