Journal
MYCOSES
Volume 54, Issue 2, Pages 131-136Publisher
WILEY
DOI: 10.1111/j.1439-0507.2009.01773.x
Keywords
Fusarium spp; amphotericin B; synergism; antifungal association
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Funding
- CNPq (the National Council for Scientific and Technological Development of Brazil)
- Laboratorio de Pesquisas Micologicas of Universidade Federal de Santa Maria, RS, Brazil
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P>Fusarium species are common hyaline soil saprophytes and plant pathogens that are opportunistic fungal pathogens of immunocompromised patients. The treatment for fusariosis remains uncertain with an unfavourable prognosis; new possibilities for treatment, such as various synergistic drug interactions, must be uncovered. In this study, we evaluated the in vitro interactions of amphotericin B with caspofungin, ketoconazole, 5-flucytosine, itraconazole, miconazole, rifampin, fluconazole, terbinafine and voriconazole against isolates of Fusarium spp. using the chequerboard method with interactions evaluated by fractional inhibitory concentration indices. The highest percentages of synergistic interactions were observed for the combinations of amphotericin B and caspofungin (68.7%), amphotericin B and rifampin (68.7%), amphotericin B plus 5-flucytosine (59.3%) and amphotericin B with voriconazole (37.5%). The pattern of susceptibility to antifungal agents among Fusarium species and their consequence on the effects of drug combinations are also discussed.
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