Journal
MYCOSES
Volume 52, Issue 4, Pages 313-317Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1439-0507.2008.01620.x
Keywords
antifungal activity; Trichophyton mentagrophytes; Candida spp; dermatophytes
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Funding
- Technion Vice-President for Research (VPR) Fund
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Dermatophyte infections, while not life-threatening, are very common, and there is great interest in developing new antifungal agents. Transcriptional profiling of Trichophyton on keratin has identified some antioxidant genes as induced on this host substrate, including a thioredoxin gene TmTRX1. If thioredoxin is a virulence factor, or necessary for the growth on keratin, thioredoxin inhibitors should act as antifungals. As a first evaluation of this hypothesis, we have tested the activity of a thioredoxin-inhibitory natural product, pleurotin, against a clinical isolate of each of two fungal pathogens: the dermatophyte T. mentagrophytes and Candida albicans. Pleurotin inhibited the growth of the dermatophyte in vitro and in an ex vivo skin model, but had no effect on Candida. It may be possible to develop and optimise thioredoxin inhibitors, some of which are already under study in cancer chemotherapy, as antifungals.
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