Journal
MYCOSES
Volume 53, Issue 6, Pages 495-499Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1439-0507.2009.01747.x
Keywords
Candida krusei; metergoline; synergism; phospholipase
Categories
Funding
- Chinese University of Hong Kong [4450125]
Ask authors/readers for more resources
P>Metergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 mu g ml-1 respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available