Journal
MYCOPATHOLOGIA
Volume 173, Issue 5-6, Pages 375-386Publisher
SPRINGER
DOI: 10.1007/s11046-011-9513-8
Keywords
Capsular polysaccharides; C. neoformans; Monocytes/macrophages; Fc receptors; Signal transduction; Apoptosis
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Funding
- European Commission, FINSysB Marie Curie Initial Training 16 Network [PITN-GA-2008-214004]
- Fondazione Cassa di Risparmio di Perugia [2010.011.0398]
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The capsule is generally considered one of the more powerful virulence factors of microorganisms, driving research in the field of microbial pathogenesis and in the development of vaccines. Cryptococcus neoformans is unique among the most common human fungal pathogens in that it possesses a complex polysaccharide capsule. This review focuses on the Cryptococcus neoformans capsule from the viewpoint of fungal pathogenesis, and the effective immune response target of the capsule's main component, glucuronoxylomannan.
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