Journal
SENSORS
Volume 15, Issue 12, Pages 31904-31913Publisher
MDPI
DOI: 10.3390/s151229893
Keywords
optical fibre; hydrogen peroxide probe; pH sensor; dual sensor; fibre tip sensor
Funding
- Cook Medical Pty Ltd
- Australian Research Council linkage grant [LP 110200736]
- ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP)
- ARC Georgina Sweet Laureate Fellowship [FL130100044]
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This paper demonstrates the first single optical fibre tip probe for concurrent detection of both hydrogen peroxide (H2O2) concentration and pH of a solution. The sensor is constructed by embedding two fluorophores: carboxyperoxyfluor-1 (CPF1) and seminaphtharhodafluor-2 (SNARF2) within a polymer matrix located on the tip of the optical fibre. The functionalised fibre probe reproducibly measures pH, and is able to accurately detect H2O2 over a biologically relevant concentration range. This sensor offers potential for non-invasive detection of pH and H2O2 in biological environments using a single optical fibre.
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