Journal
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Volume 705, Issue 2, Pages 77-82Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrrev.2010.04.004
Keywords
Biomarkers; Carcinogenicity; Molecular epidemiology
Funding
- Associazione ltaliana per la Ricerca sul Cancro
- Environmental Cancer Risk, Nutrition and Individual Susceptibility European Union Network of Excellence (ECNIS) [FOOD-CT-2005-513943]
- NIH [5P20CA132385-03]
- NATIONAL CANCER INSTITUTE [P20CA132385] Funding Source: NIH RePORTER
- Medical Research Council [G0801056B] Funding Source: researchfish
Ask authors/readers for more resources
Objectives: There is some evidence that dietary components that are rich in antioxidant and vitamins are inversely associated with DNA adduct levels induced by environmental carcinogens such as polycyclic aromatic hydrocarbons, although the epidemiologic data are inconsistent. This study addresses the association between vitamins. DNA adducts and smoking. Methods: A combined analysis of individual data on the association between bulky DNA adducts and dietary vitamins was conducted. A Medline search was performed to identify studies on healthy subjects in which smoking and vitamins intake information were available, and bulky DNA adducts were measured in peripheral blood with 32P-postlabelling. Eight published studies met the eligibility criteria, and individual data from 7 data sets including 2758 subjects were obtained. GSTM1 and GSTT1 were also available on all the subjects. Results: Vitamin E was inversely significantly associated with DNA adducts after adjustment for possible confounding factors. Vitamins A and C were not independent predictors of DNA adducts. A stratified analysis showed that vitamin A had a significant inverse association with DNA adducts in ever smokers only. Conclusions: This result is relevant to planning any future chemo-preventive interventions directed to high risk subgroups of the population, for cancer prevention. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available