Journal
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Volume 703, Issue 1, Pages 11-17Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrgentox.2010.08.021
Keywords
8-oxodG; Nucleotide pool oxidation; Salvage; Accelerator mass Spectrometry; DNA repair
Funding
- Susan and Gerry Knapp Foundation, National Institutes of Health [RR13461]
- California Breast Cancer Research Program [9KB-0179]
- European Union [513943]
- World Cancer Research Fund
- ECNIS
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Recent evidence suggests that salvage of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of 8-oxoGua in DNA and RNA. However, it remains to be determined if this mechanism contributes to mutagenesis and disease. This review covers the predominant methods for detecting 8-oxoGua and its derivatives, summarizes some of the relevant recent DNA repair studies and discusses the mechanisms for metabolism of oxidized guanine derivatives in the (2'-deoxy)ribonucleoside and (2'-deoxy)ribonucleotide pools. (C) 2010 Elsevier B.V. All rights reserved.
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