Circadian rhythms and chemical carcinogenesis: Potential link. An overview

Circadian rhythm is an integral and not replaceable part of the organism's homeostasis. Its signalling is multidimensional, overlooking global networks such as chromatin remodelling, cell cycle, DNA damage and repair as well as nuclear receptors function. Understanding its global networking will allow us to follow up not only organism dysfunction and pathology (including chemical carcinogenesis) but wellbeing in general having in mind that time is not always on our side. (C) 2009 Elsevier B.V. All rights reserved.