Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 759, Issue -, Pages 9-15Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2013.11.006
Keywords
Radiation-induced bystander effect; Carbon monoxide; Proliferation; Chromosome aberration
Funding
- National Natural Science Foundation of China [31000384, 81172602]
- Hundred Talents Program of the Chinese Academy of Sciences
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Radiation-induced bystander effect (RIBE) has been proposed to have tight relationship with the irradiation-caused secondary cancers beyond the irradiation-treated area after radiotherapy. Our previous studies demonstrated a protective effect of low concentration carbon monoxide (CO) on the genotoxicity of RIBE after a-particle irradiation. In the present work, a significant inhibitory effect of low-dose exogenous CO, generated by tricarbonyldichlororuthenium (II) dimer [CO-releasing molecule (CORM-2)], on both RIBE-induced proliferation and chromosome aberration was observed. Further studies on the mechanism revealed that the transforming growth factor beta 1/nitric oxide (NO) signaling pathway, which mediated RIBE signaling transduction, could be modulated by CO involved in the protective effects. Considering the potential of exogenous CO in clinical applications and its protective effect on RIBE, the present work aims to provide a foundation for potential application of CO in radiotherapy. (C) 2013 Elsevier B.V. All rights reserved.
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