Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 711, Issue 1-2, Pages 150-157Publisher
ELSEVIER
DOI: 10.1016/j.mrfmmm.2011.02.012
Keywords
DNA damage; Ionizing radiation; Cancer therapy; Gene expression; Mutagenesis
Funding
- NIH [R01 GM084020]
- NSF [154-5174/SPO68027]
- Nanosonic, Inc. [N-A85P]
- NASA [RE01701, RE01301]
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Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and gamma-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation. (C) 2011 Elsevier B.V. All rights reserved.
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