Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 685, Issue 1-2, Pages 45-53Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2009.08.002
Keywords
Replication fork; DNA polymerases; Replication origins
Funding
- NCI NIH HHS [R01 CA129925, R01 CA129925-01A2, CA129925, R01 CA129925-01A2S1, R01 CA129925-02] Funding Source: Medline
- NIEHS NIH HHS [R01 ES015869-01A2, ES015869, R01 ES015869] Funding Source: Medline
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Function of the eukaryotic genome depends on efficient and accurate replication of anti-parallel DNA strands. Eukaryotic DNA polymerases have different properties adapted to perform a wide spectrum of DNA transactions. Here we focus on major players in the bulk replication, DNA polymerases of the B-family. We review the organization of the replication fork in eukaryotes in a historical perspective, analyze contemporary models and propose a new integrative model of the fork. (C) 2009 Elsevier B.V. All rights reserved.
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