Journal
MUTAGENESIS
Volume 24, Issue 4, Pages 285-293Publisher
OXFORD UNIV PRESS
DOI: 10.1093/mutage/gep010
Keywords
-
Categories
Funding
- Medical Research Council [G0700865/82417]
- The Colt Foundation
- Research Councils UK Academic Fellowship [EP/E500609/1]
- Engineering and Physical Sciences Research Council Advanced Research Fellowship [EP/E059678/1]
- Institute for Materials Research, University of Leeds
- Leeds EPSRC Nanoscience and Nanotechnology Research Equipment Facility [EP/F056311/1]
- EPSRC [EP/E059678/1] Funding Source: UKRI
- MRC [G0700865] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E059678/1, EP/C540026/1] Funding Source: researchfish
- Medical Research Council [G0700865] Funding Source: researchfish
Ask authors/readers for more resources
The development of novel nanomaterials with unique physico-chemical properties is increasing at a rapid rate, with potential applications across a broad range of manufacturing industries and consumer products. Nanomaterial safety is therefore becoming an increasingly contentious issue that has intensified over the past 4 years, and in response, a steady stream of studies focusing on nanotoxicology are emerging. However, it is becoming increasingly evident that nanomaterials cannot be treated in the same manner as chemical compounds with regards to their safety assessment, as their unique physico-chemical properties are also responsible for unexpected interactions with experimental components that generate misleading data-sets. In this report, we focus on nanomaterial interactions with colorimetric and fluorometric dyes, components of cell culture growth medium and genotoxicity assay components, and the resultant consequences on test systems are demonstrated. Thus, highlighting some of the potential confounding factors that need to be considered in order to ensure that in vitro genotoxicity assays report true biological impacts in response to nanomaterial exposure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available