Journal
MUSCLE & NERVE
Volume 48, Issue 3, Pages 423-429Publisher
WILEY
DOI: 10.1002/mus.23768
Keywords
electromyography; facial nerve; nerve conduction; nerve regeneration; Schwann cells; stem cells
Categories
Funding
- INCT Program Project of the National Council for Scientific and Technological Development
- CNPq, Brasilia, Brazil [573633/2008-8]
- Sao Paulo Research Foundation
- FAPESP [CEPID 1998/14254-2, 2008/53857-8, 2008/00458-9]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [98/14254-2, 08/00458-9] Funding Source: FAPESP
Ask authors/readers for more resources
IntroductionSevere lesions in the facial nerve may have extensive axonal loss and leave isolated stumps that impose technical difficulties for nerve grafting. Methods: We evaluated bone marrow stem cells (BMSC) in a silicone conduit for rat facial nerve regeneration from isolated stumps. Group A utilized empty silicone tubes; in groups B-D, the tube was filled with acellular gel; and, in groups C and D, undifferentiated BMSC (uBMSC) or Schwann-like cells differentiated from BMSC (dBMSC) were added, respectively. Compound muscle action potentials (CMAPs) were measured, and histology was evaluated. Results: Groups C and D had the highest CMAP amplitudes. Group C had shorter CMAP durations than groups A, B, and D. Distal axonal number and density were increased in group C compared with groups A and B. Conclusions: Regeneration of the facial nerve was improved by both uBMSC and dBMSC in rats, yet uBMSC was associated with superior functional results.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available