Journal
MUSCLE & NERVE
Volume 45, Issue 3, Pages 431-433Publisher
WILEY-BLACKWELL
DOI: 10.1002/mus.22322
Keywords
cross-sectional area; corticosterone; muscle atrophy; paradoxical sleep deprivation; testosterone
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Funding
- Associacao Fundo de Incentivo a Pesquisa (AFIP)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2009/11056-1]
- CEPID/SONO-FAPESP [98/14303-3]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Universidade Federal de Sao Paulo (UNIFESP)
- Fundo de Auxllio aos Docentes e Alunos (FADA)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [98/14303-3] Funding Source: FAPESP
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Introduction: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleepdeprived rats.Methods: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. Results: PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. Conclusion: PSD induces hormonal alterations that may mediate muscle atrophy. Muscle Nerve, 2012
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