Journal
MUSCLE & NERVE
Volume 45, Issue 2, Pages 274-276Publisher
WILEY-BLACKWELL
DOI: 10.1002/mus.22295
Keywords
flavones; muscle fatigue; neuromuscular transmission failure; neurotrophins; synaptic efficacy
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Funding
- NIH [HL096750, AR051173]
- Mayo Clinic
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Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors. Using TrkBF616A mice that are susceptible to specific inhibition of TrkB activity by 1NMPP1, we show that neuromuscular transmission is enhanced by 7,8-DHF (?32%) via activation of TrkB in diaphragm muscle. The small molecule 7,8-DHF may constitute a novel therapy to improve neuromuscular function. Muscle Nerve, 2012
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