Journal
MUSCLE & NERVE
Volume 44, Issue 3, Pages 318-331Publisher
WILEY
DOI: 10.1002/mus.22094
Keywords
biomechanics; collagen; extracellular matrix; fibrosis; skeletal muscle
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Funding
- Department of Veterans Affairs (NIH) [R24HD050837]
- NSF
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The skeletal muscle extracellular matrix (ECM) plays an important role in muscle fiber force transmission, maintenance, and repair. In both injured and diseased states, ECM adapts dramatically, a property that has clinical manifestations and alters muscle function. Here we review the structure, composition, and mechanical properties of skeletal muscle ECM; describe the cells that contribute to the maintenance of the ECM; and, finally, overview changes that occur with pathology. New scanning electron micrographs of ECM structure are also presented with hypotheses about ECM structure-function relationships. Detailed structure-function relationships of the ECM have yet to be defined and, as a result, we propose areas for future study. Muscle Nerve 44: 318-331, 2011
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