Journal
MUSCLE & NERVE
Volume 44, Issue 6, Pages 987-989Publisher
WILEY-BLACKWELL
DOI: 10.1002/mus.22250
Keywords
glutamate; mammalian neuromuscular junction; NMDA receptors; postsynaptic membrane; skeletal muscle
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Funding
- RFBR [09-04-01280, 11-04-01471, 11-04-01188]
- Russian Federation [64631.2010.7, 8017.2010.4]
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In this study we demonstrate expression of the N-methyl-D-aspartate receptor NR1 subunit in the rat neuromuscular junction of skeletal muscles of different functional types (extensor digitorum longus, soleus, and diaphragm muscles) using fluorescence immunocytochemistry. Electron microscopic immunocytochemistry has shown that the NR1 subunit is localized solely on the sarcolemma in the depths of the postsynaptic folds. These findings suggest participation of the glutamatergic signaling system in functioning of the adult mammalian neuromuscular junction. Muscle Nerve 44: 987-989, 2011
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