Journal
MUSCLE & NERVE
Volume 43, Issue 6, Pages 897-899Publisher
WILEY-BLACKWELL
DOI: 10.1002/mus.22037
Keywords
conduction block; high-frequency alternating current (HFAC); large diameter; peripheral nerve; primate
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Funding
- National Institute of Neurological Disorders and Stroke [NS053603]
- Searle Foundation Chicago Community Trust
- National Institute of Biomedical Imaging and Engineering [R01-EB-002091]
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Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block. Muscle Nerve 43: 897-899, 2011
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